New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in ...

Ishii and colleagues now reveal that TBK1 (TANK-binding kinase 1) mediates the adjuvant effect of DNA vaccines and that this effect occurs independently of the TLR (Toll-like receptor) signalling ...

More information: Elias Adriaenssens et al, Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD, Nature Structural & Molecular Biology (2024). DOI: 10.1038 ...

Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome.