SUMO (red) is covalently linked to the TOG2 domain of Stu1, a microtubule associated protein (blue). When Stu1 is SUMOylated the protein abundance is increased by 442% in simulated microgravity ...

Researchers at Goethe University, Johannes Gutenberg University Mainz and Kiel University discover possible method for preventing protein aggregates – Cluster4Future PROXIDRUGS research project.

The discovery of the twisting switch resolves a long-standing question about how the DNA repair protein RNF168, which has a tendency to cause uncontrolled signaling, is switched off. The paper ...

If the protein TDP-43 is defective inside a nerve cell it can form neurotoxic aggregates, which are the cause of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Nerve cells are also ...