A 72-year-old woman with type 2 diabetes had somnolence after a urologic procedure for bladder cancer. She had respiratory acidosis and anion-gap metabolic acidosis. A diagnosis was made.

“Based on the findings in Marinus’ Phase 2 TSC trial, the titration schedule of ganaxolone was modified in the Phase 3 TrustTSC trial with the goal of reducing the frequency of somnolence ...