Dynamin is a large GTPase that participates in the severing of membrane-bound vesicles. A small-molecule inhibitor specific for the dynamin family of GTPases has been identified and reveals new ...

Further, one part of the GTPase domain, the COR domain, has no known small molecule binding sites where drugs could attach themselves. "This is a very understudied area," Xiong says. "There is not ...

The study showed that live internalizing cells actively participate in the invasion process, in a manner dependent on signalling through the small GTPase Rho, which mediates actomyosin-mediated ...

The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...