At least 20 people in Chari and Ashlyne’s immediate extended family have a SMAD4 gene mutation, which leads to unchecked cell growth and can cause cancer throughout the digestive tract.

METTL3, an oncogene regulates the expression of SMAD4, a tumor-suppressor via miR-146a-5p, thus unveiling a novel regulatory axis ...

Figure 8: Schematic representation of METTL3-mediated OSCC progression via regulating the miR-146a-5p/SMAD4 axis. Overexpressed METTL3 (an oncogene) in OSCC cells enhances the processing of pri ...

A new research paper was published in , Volume 16, on May 8, 2025, titled "METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis." ...