Therefore, future research targeting CRP or the Smad3-NLRP3 mechanism may provide new treatment directions for DKD. The findings were published in the journal Molecular Therapy and featured as the ...

TβRI then phosphorylates the carboxyl terminus of the transcription factors SMAD2 and SMAD3, enabling them to form a complex with SMAD4. This Smad complex translocates to the nucleus to regulate ...