[1–4] The insulin secretory defect in T2D is multifactorial ... We have identified four genetic variants that confer reduced β-cell exocytosis and six variants that interfere with insulin ...

"Until our collaborative study, exocyst was understood to recognize and possibly tether secretory vesicles to the cell membrane, prior to exocytosis. In this study, we reveal biophysical studies ...

Ever since George Palade's pioneering studies of zymogen secretion from pancreatic acinar cells, the underlying molecular mechanisms of vesicle-mediated protein transport have captivated cell ...

Diabetes. 2012;61(7):1726-1733. We examined exocytosis by measurements of cell capacitance that monitor the increase in cell area that results when secretory granules fuse with the plasma membrane.