These metabolites can have similar effects to the SSRI and effectively prolong the half-life of the drug. So fluoxetine, which has quite a long half-life and an active metabolite, rarely triggers ...

We surveyed 400 psychiatrists to assess depressive relapse during ongoing selective serotonin reuptake inhibitor (SSRI) treatment and the common strategies to regain remission. Among 119 ...

Kennedy — who is not a physician and has no medical or public health training — has said that the class of drugs known as selective serotonin reuptake inhibitors, or SSRIs, are harder to give ...

Antidepressants with a long half-life—such as sertraline and fluoxetine—only cause the syndrome in about 2% of people. Other studies suggest that discontinuation syndrome may be as high as 40% ...