In terms of combating malaria, the Ss genotype has an advantage over both the SS genotype, because it results in malarial resistance, and the ss genotype, because it does not cause sickling crises.

For adults with sickle cell disease (SCD), C-reactive protein (CRP) levels increase significantly during the follicular phase ...

For adults with sickle cell disease, C-reactive protein levels increase significantly during the follicular phase of the menstrual cycle.