In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department of Chemistry Professor Jun Zhang, Ph.D., and his team reveal how the protein SRSF1 possesses the ...

As SRSF1 genomic amplification is preferentially observed in breast tumors, but several other genes are coamplified on chromosome 17q23, we investigated whether SRSF1 can transform mammary ...

Together with the critical regulator protein SRSF1, DDX23 helps set the stage for RNA splicing. One of those regulators, a protein called SRSF1, has been a focus of Krainer's lab since 1990.

SRSF1 is a protein with many jobs. It was first described as necessary for the process in which mRNA, the messenger molecule transcribed from DNA to act as the template by which proteins are made ...

One of those regulators, a protein called SRSF1, has been a focus of Krainer's lab since 1990. It was then that he discovered cells need SRSF1 for splicing to occur. His team has since found that ...

Scientists have discovered a strong link between the protein SRSF1 and pancreatic cancer in mice. High levels of SRSF1 appear to cause inflammation or pancreatitis, which can lead to PDAC.

The team zeroed in on a splicing-regulator protein called SRSF1. They found that high levels of SRSF1 cause inflammation or pancreatitis. This jumpstarts PDAC tumor development. "Cells have ...

Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new ...

There are 12 members of the SR protein family. This family of RNA-binding proteins is most known for RNA splicing. SRSF1 oversees the splicing of over 1,500 different messenger RNA transcripts. “The ...

Together with the critical regulator protein SRSF1, DDX23 helps set the stage for RNA splicing. Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task ...