Onwuegbusi and colleagues, therefore, investigated the effects of alterations in TGF-β signaling on cell proliferation and ... cycle arrest and induction of SMAD-dependent gene transcription ...
The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell ...
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