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SIRT5, a "longevity protein," plays a crucial role in delaying age-related skeletal muscle decline by modulating inflammatory pathways through its interaction with TBK1. In a primate model, SIRT5 ...
More information: Qian Zhao et al, SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1, Nature Metabolism (2025). DOI: 10.1038/s42255-025-01235-8 Provided by ...