However there has been no indication from Cbl's sequence that it contained an SH2 domain — the archetypal phospho-tyrosine binding motif. Consequently the recent structure of Cbl from Michael ...

Adam Kashishian (Fred Hutchinson Cancer Research Center, Seattle): "The question of the specificity of Src homology 2 (SH2) domain/phosphotyrosine interactions has been an important one since the ...

These phosphotyrosine interaction domains have three distinct biological roles: (i) recruiting SH2 or PTB domain-containing proteins to tyrosine-phosphorylated and activated receptor tyrosine ...