Taking the drug causes cGMP to build up, amplifying its relaxing effects on the blood vessels. SGC is a substance produced in the body that causes the blood vessels in the lungs to dilate (become ...

One key pathway is the soluble guanylyl cyclase–cyclic GMP–protein kinase G system. If it is produced in excess, or if a cell is under conditions of oxidative stress, NO becomes noxious and ma ...