One possible target is a protein called Nav1.7, a sodium channel found in sensory neurons. Mutations in the gene SCN9A, which encodes this protein, can make people either hypersensitive to pain or ...

Individuals with loss-of-function mutations in the SCN9A gene (which encodes the alpha-subunit of Na V 1.7) experience a complete inability to sense pain (Cox et al., 2006) while those with a gain ...

The presentations will be made at the 28th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT ... NHP CNS tissue with AAV9. In our SCN9A-targeted pain program, we have achieved ...