Ludwig-Maximilians-Universität München-led researchers have induced a greater than 60% reduction in seizure frequency in a preterm infant with early-onset SCN2A developmental and epileptic ...

The gene, SCN2A, makes an ion channel that is found throughout the brain, including the region that coordinates movement, called the cerebellum. Ion channels allow electrical charges in and out of ...

A telltale sign of autism in an eye reflex Of the hundreds of gene mutations associated with autism, variants of the SCN2A gene are among the most common. Since autism affects social communication ...

Investor focus shifts to the epilepsy pipeline, led by vormatrigine (focal epilepsy) and relutrigine (SCN2A/SCN8A-DEEs). Vormatrigine must differentiate from Xcopri and XEN1101 in a highly ...

Researchers from the University of San Francisco (UCSF) found that children carrying a variant of the SCN2A gene, which is associated with severe ASD, had a hypersensitive vestibulo-ocular reflex (VOR ...

The EMBOLD Study is expected to initiate in the U.S in the first quarter of 2023, with two distinct cohorts in early-onset SCN2A-DEE and SCN8A-DEE patients. Topline results for both cohorts are ...

As a result, we have rapidly advanced the SCN2A/8A program to registrational stage and are expanding our studies to cover a broader range of DEEs” said Marcio Souza, president and chief ...

We also presented the EMBRAVE3 design for elsunersen in SCN2A gain-of-function (GoF) patients. This is not only the shortest known trial for an antisense oligonucleotide (ASO) but also supports a ...

That was the day his first son, Roger, was born with an extremely rare genetic epilepsy (SCN2A mutation) that currently has no cure. Roger started having seizures within hours of his birth ...