Infection was absent in ACE2 knockout cells and restored upon ACE2 ... The spike protein's S1/S2 and S2 cleavage sites were ...

In preclinical studies, ABS-VIR-001 shows more potent S1 binding, blocking of S1–ACE2 interaction and SARS-CoV-2 neutralization than a combination of individual monoclonal VHH-Fcs. These data ...

Sino Biological has developed a recombinant S1 protein with a D614G mutation (40591-V08H3). The recombinant 614G variant demonstrated an ACE2 binding activity. In addition to the D614G mutation, ...