They also showed that a gene called RUNX2 is activated in primary bone cancer and that this gene is associated with driving the cancer's spread. They went on to develop CADD522, a small molecule ...

More information: Yu Yamashita et al, Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation, Nature Communications (2025). DOI: 10.1038/s41467-024-55451-z ...