Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that ...

A team of researchers led by Ana García-Sáez and Uris Ros has discovered that cells possess a built-in mechanism to regulate necroptosis using two forms of MLKL: a regular variant of MLKL that gets ...

The conversion between apoptosis and necroptosis has also been implicated in retinal diseases, as the loss of RIP3 expression prevents the formation of reactive oxygen species (ROS), thereby ...

Tumor cell deaths can benefit tumors. A paradox? Not at all. If, for example, a dying tumor cell undergoes necroptosis, it can release inflammatory factors that can enhance or diminish antitumor ...

Strikingly, this signal relay is known to trigger a specific, injury-induced form of cell death, referred to as necroptosis. Furthermore, the observations strongly suggest that necroptosis is in ...

To address this issue, Prof. Nakano's group previously developed a biosensor for necroptosis called SMART (Sensor for MLKL activation by RIPK3 based on FRET). This biosensor is designed based on ...

Oxidative stress can trigger a type of programmed cell death called necroptosis. According to a new study, the environmental pollutant arsenite can induce necroptosis, but the process requires the ...

BUFFALO, NY- April 24, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on April 10, 2023, entitled, “Tumor necroptosis promotes metastasis through modulating the interplay ...

The research team has found the first evidence that the activation of a biological pathway called necroptosis, which causes neuronal loss, is closely linked with Alzheimer’s severity, cognitive ...