The large subunit rRNA, in particular, is responsible for the peptidyl transferase reaction, which catalyzes the formation of peptide bonds between amino acids during protein synthesis. This discovery ...

In fact, rRNA is sometimes called a ribozyme or catalytic RNA to reflect this function. Eukaryotic and prokaryotic ribosomes are different from each other as a result of divergent evolution.

To achieve this, the researchers designed a small ribozyme-based RNA molecule (also called catalytic RNA) that attached a ...

For example, the ribosome itself is a ribozyme, as the rRNA component catalyzes the formation of peptide bonds during protein synthesis. Other ribozymes include self-splicing introns and the RNA ...

There are three types of RNA involved in the translation process: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). Although some RNA molecules are passive copies of DNA ...

A major focus of our lab is to harness the power of small catalytic RNAs (such as the hammerhead ribozyme) to create new RNA switches that can be turned on or off by small molecules. One of the ...