The Rho GTPases are potent regulators of the actin cytoskeleton and consequently influence many aspects of cell shape and movement. In vivo, Rho activity appears to be a critical determinant of ...

Keywords regulation of intracellular traffic and the actin cytoskeleton by rho family gtpases Areas of expertise Rho GTPases act as molecular switches that control a wide range of signalling pathways ...

This issue is even more of a concern when analogous dominant-inhibitory versions of Rho-family GTPases, such as Rho, Rac and Cdc42, are used. Many of the nucleotide-exchange factors for these ...

Laboratory of Dr. Jonathan Chernoff, Fox Chase Cancer Center (1998-99). Role of Rho GTPases in axonal guidance. Laboratory of Dr. Gianluca Gallo, Drexel University College of Medicine (2003-06) While ...

The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...

Our research employs broad interdisciplinary approaches in cell and molecular biology and genetics, with special expertise in quantitative live-cell imaging. We also collaborate closely with engineers ...