as mutant Ras proteins that lack GTPase activity, which normally turns Ras off, were found in many types of human tumours. We now know that, depending on the cellular context, Ras can contribute ...

How does Ran GTPase control both protein import during interphase and spindle attachment to the chromosomes during M-phase? It all has to do with its concentration gradient in the cell.

The laboratory experiments turned up gold: with the help of G12C, some of the K-Ras drugs bound to the otherwise featureless GTPases. When G12C was removed, those drugs still bound to the GTPase ...