Rab5, in particular, is an essential regulator of endocytosis 6,7,8,9,10 and mediates early endosome fusion in concert with the SNARE machinery 11,12. In its active state, Rab5 is localized on the ...

Down syndrome (DS) is the most prevalent genetic cause of Alzheimer’s disease (AD). Previous evidence suggests that increased dosage of the amyloid precursor protein (APP) gene plays a crucial role in ...

These organelles are positive for the marker GTPase Rab5 and here cargo is sorted and recycled. Alternatively, the content is delivered to the lysosome for degradation, which requires the maturation ...

Our lab is interested in the molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible ...