He added: “We have seen no significant gene misregulation attributable to ... chromosomal abnormalities and mutations in the RUNX1 and PTPN11 genes typically associated with the development ...

The action of Runx1 seems to govern the development of a wide variety of classes of nociceptive neurons, and the authors conclude: “The identification of a core transcriptional control program ...

Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA.