Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription. J Mol Biol 2022, 433: 167216. Schier, A; Taatjes, DJ. Everything at once: ...

To do this they needed to visualize the structural architecture of the chloroplast RNA polymerase. The research team used a method called cryogenic electron microscopy (cryo-EM) to image samples ...

Here, the authors combine biochemistry, NMR, and cryo-EM to show that spontaneous ... The critical events in transcription termination of RNA polymerase II (Pol II) remain not fully understood.

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Now, researchers used cryoelectron microscopy (cryo-EM) to elucidate the structure of the Nipah virus polymerase complex ... for both transcription and RNA replication and mutations that have ...