TFIID enables RNA polymerase II promoter-proximal pausing. Mol Cell 2020, 78: 785 – 793. Schier, AC; Taatjes, DJ. Structure and mechanism of the RNA polymerase II transcription machinery. Genes Dev.

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD ...

An RNA polymerase II molecule is about 15 nanometers across, or roughly 5,000 times smaller than the width of a human hair. This image was created by reconstructing X-ray diffraction crystallography ...

Researchers at Fred Hutch and MD Anderson discovered RNA Polymerase II on histone genes as a biomarker for cancer ...

It both stabilizes a critical protein called RNA Polymerase II—the molecular engine of gene transcription—and reshapes the structure of chromatin, the tightly packed form of DNA, to activate ...

Chromatin structure allows activators to associate ... result of TFs that govern the way genes are transcribed and RNA polymerase II is recruited. Through these mechanisms, TFs control important ...

Overview of RNA ... (ii) developing a kinetic mechanism for the healing and sealing steps; (iii) highlighting distinctive kinetic properties and NTP specificities of the kinase components of fungal ...

Now, researchers used cryoelectron microscopy (cryo-EM) to elucidate the structure of the Nipah virus polymerase complex ... for both transcription and RNA replication and mutations that have ...

In DNA, two complementary strands of nucleotides pair up through hydrogen bonds between the bases (A with T and G with C) to form the iconic double helix structure ... RNA through the process of ...