Spermidine is a natural polyamine found in cells whose post-translational acetylhypusination regulates key proteins like receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Aging ...

Figure 1: ZBP1 induces keratinocyte necroptosis and skin inflammation in RIPK1 E-KO mice. Figure 2: Mutation of the RIPK1 RHIM domain causes perinatal lethality and inflammatory skin hyperplasia ...

Sironax' lead RIPK1 drug, SIR0365, has completed two phase 1b studies including one looking at its potential as a treatment for severe hyperinflammation associated with COVID-19 infections, while ...

SAR443820 is a central nervous system (CNS)-penetrant investigational small molecule inhibitor of RIPK1. “Multiple sclerosis is a chronic and disabling, inflammation-mediated neurodegenerative ...

Just one year ago, encouraging preclinical data saw GlaxoSmithKline kick-start a new clinical test of its investigational RIPK1 inhibitor GSK095. Now, the drug’s test in a tough-to-beat cancer ...

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Researchers at the China Pharmaceutical University have developed a series of highly active receptor-interacting protein kinase 1 (RIPK1) inhibitors with potent anti-inflammatory activity. RIPK1 is a ...

Eli Lilly has penned a research and sales pact with Rigel Pharmaceuticals for its experimental med R552, a receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor. The pact ...

In order to bring about this type of cell death, scientists at The Institute of Cancer Research, London, targeted a protein called RIPK1, which plays a vital role in helping cancer cells survive ...

Denali and Sanofi entered into a broad collaboration in October 2018 for the global development and commercialization of RIPK1 inhibitors. This includes peripherally restricted molecules such as ...

When TBK1 is lost or mutated, it fails to perform its protective role, allowing two major cell death pathways, RIPK1 and NLRP3, to become overactive. This overactivity leads to excessive cell ...