In the alternate pathway initiated by double-stranded breaks ... RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the ...

The primary job of BRCA2 is to regulate RAD51, a key player in the accurate ... maintaining the integrity and function of DNA repair pathways. "Cancer cells can somehow tolerate the loss of ...

For many of these pathways, scientists have long known the ... interested in dynamic single-molecule analysis when studying RAD51 — an enzyme regulated by BRCA2 to repair double-strand DNA ...

The primary job of BRCA2 is to regulate RAD51, a key player in the accurate ... maintaining the integrity and function of DNA repair pathways. Cancer cells can somehow tolerate the loss of the ...