The primary job of BRCA2 is to regulate RAD51, a key player in the accurate recombination of DNA during cell division. The researchers found, to their surprise, that when PARP inhibitors ...

RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...