The primary job of BRCA2 is to regulate RAD51, a key player in the accurate ... maintaining the integrity and function of DNA repair pathways. "Cancer cells can somehow tolerate the loss of ...

Multiple RAD51 proteins bind along the length of broken ... double-strand breaks in DNA and could be a useful target for new cancer therapies. “It was really cool — nobody had seen that ...

This study aimed to elucidate the genetic associations of seven pivotal genes with breast cancer and discern their potential ...

RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...

This reaction is carried out by the RecA/Rad51 family of ATPases ... This error-free form of DSB repair is crucial in preventing genomic abnormalities that can cause cancer. In fact, many of the ...