RAD51 is a protein involved in homologous recombination repair (HRR) alterations. Developed in-house by Serra's laboratory, the RAD51 assay is based on the detection of this protein as a ...

Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation—can predict an individual's predisposition ...

RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...