Lily Cieslinski was diagnosed with Pyruvate Dehydrogenase Complex Deficiency in 2024. Her parents held a fundraiser to ...

After more than five decades of mystery, scientists have finally unveiled the detailed structure and function of a ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria allows us ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

Pyruvate and related metabolites are linked to reduced glaucoma risk among genetically predisposed individuals and mitigate disease in a mouse model, highlighting a potential metabolic mechanism of ...

After 50 years of mystery, researchers at the University of Cambridge have revealed how a molecular machine inside ...

Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...

This stage does not require oxygen. If oxygen is available to the cell then the pyruvate molecules can be further broken down in stage two to release more energy and produce a greater quantity of ATP.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...