Co-crystallization of any FYVE domain construct with a soluble PtdIns(3)P mimic has not yet proved possible. Happily the path taken by Overduin and colleagues with their heteronuclear NMR ...

Using fluorescence imaging approaches, the authors observed the rapid translocation of cofilin from the plasma membrane that was dependent on PLC-mediated PtdIns(4,5)P 2 hydrolysis. Cofilin was ...