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Control of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P 3) signals in cell survival, proliferation and growth is frequently dysfunctional in cancer, resulting in enhanced PtdIns(3,4,5 ...
The PI3K pathway is tightly controlled by a class of PI3Ks that generate the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P 3), and the tumor suppressor PTEN ...
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