One of the key challenges is that PBC is often underreported due to its subtle onset and the non-specific nature of early symptoms. 2 Common symptoms like fatigue and pruritus (chronic itch ...

Cholestatic pruritus is a common symptom of primary biliary cholangitis (PBC), a rare autoimmune liver disease. Researchers are looking to establish the safety and efficacy of linerixibat – an ...

Data from Mirum studies presented at DDW, EASL, and ESPGHAN congresses "We are excited to see the continued evidence ...

People with liver disease often have high levels of bilirubin. In 2021, some researchers found evidence that itching with PBC might involve a nerve reaction in keratinocytes, cells in the skin’s ...

Gilead Sciences, Inc. (Nasdaq:GILD) today announced new research to be presented at the European Association for the Study of ...

GSK has reported promising results with a drug to treat the severe itching that plagues patients with rare cholestatic liver disease primary biliary cholangitis (PBC). Interim results from the ...

Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis ... The most common initial signs are a feeling of chronic fatigue and pruritus (itchy skin). As primary biliary ...

Volixibat has been granted Breakthrough Therapy Designation for the treatment of cholestatic pruritus in patients with PBC. Mirum is also planning for a Phase 2 study evaluating MRM-3379 ...

“In particular, we look forward to sharing updated data from the interim analysis of the VANTAGE study of volixibat in patients with pruritus due to PBC. We are encouraged by the positive ...