Normal animal cells make a form of PrP that is called cellular PrP (abbreviated PrPC). Animals infected with prions make abnormal PrP. In scrapie, abnormal PrP is called PrPSc. The abnormal ...

White et al. injected anti-PrP monoclonal antibodies with high affinity for both murine PrPC and PrPSc into individual mice from a scrapie model strain. They observed that peripheral PrPSc levels and ...

During the current study, Nicola Franscini and colleagues at Case Western University School of Medicine, detected prion protein (PrPC)-the precursor of prions (PrPSc)-in milk from humans ...

The test sample contains PrPSc oligomers, the ill-defined aggregates representing the minimal infectious prion units. Incubation of the sample with brain homogenate, containing PrPC and possibly ...

The characteristic diagnostic signs of prion disease in humans and animals, such as changes in behavior and mobility, result from advanced neurodegeneration for which there is currently no cure.

The molecule is miR-519a-3p, a microRNA directly linked to the expression of the cellular prion protein (PrPC), which is deregulated in people suffering from some neurodegenerative diseases such ...

The molecule is miR-519a-3p, a microRNA directly linked to the expression of the cellular prion protein (PrPC), which is deregulated in people suffering from some neurodegenerative diseases such ...