If there is no nucleic acid, how are agent properties specified? Secondly, PrP (sometimes called prion protein) , is associated with the agent somehow - but what does it do? This debate matters ...

Knight says that the method of transmission that Collinge identified is “extremely unusual,” and there’s no evidence that Alzheimer’s can spread through medical procedures used today. He also conceded ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

Some prion diseases have been associated with familial mutations in the gene encoding the prion protein (PrP). However, how these mutations contribute to the disease process was not well understood.

These observations suggest that a diagnostic test for prion infections based on CSF or other non-brain tissues or excretia may be possible. Further studies will be required to demonstrate the ...

Preventing new transmissions of the prion protein (PrP) isoforms that cause spongiform encephalopathies requires reliable diagnostic tests. In October 21 Nature Biotechnology, Jiri G. Safar and ...

According to the prion hypothesis, championed by American neurologist and biochemist Stanley Prusiner, this lethal protein can be likened to the "evil twin" of a normal protein called PrP ...