In other words, PrPSc converts PrPC into PrPSc. Prions do not contain a nucleic acid genome J.S. Griffith first proposed the protein-only theory in 1967 to explain how prions could replicate if ...

The ‘Molecular Devils’ That Cause the Most Fatal Diseases Ever Known CJD and similar brain diseases are caused by a misfolded version of the naturally occurring prion protein. When these rogue ...

There are some scientists who say that because the prion does not contain its own genetic material it cannot be an infectious agent. Stanley Prusiner of the University of California, who first ...

The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in the U.S., which coordinates autopsies and neuropathologic examinations of suspected prion disease ...

This "mini prion" induces misfolding in normal tau, and its behavior is influenced by water structure around the protein, particularly by the P301L mutation. These findings may aid in developing ...

The characteristic diagnostic signs of prion disease in humans and animals, such as changes in behavior and mobility, result from advanced neurodegeneration for which there is currently no cure.

Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...

Mark Purdey was an organic farmer turned self-taught scientist who developed the theory that organophosphate pesticides had caused cow prion proteins to go rogue, causing BSE. Over the years ...

According to the Centers for Disease Control and Prevention, CWD is a highly contagious and fatal disease that is caused by an abnormal protein called a “prion” that affects deer, elk ...