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How a former navy mechanic defied the genetic odds of inherited Alzheimer's disease
Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant ...
Nature9mon
Presenilin and the UPR
Disruption of calcium homeostasis, inhibition of protein glycosylation, and various cellular stresses provoke the accumulation of unfolded protein in the endoplasmic reticulum (ER); this ...