Causes: POLG-related diseases are caused by several hundred different mutations in the POLG gene. This gene encodes a protein in mitochondria, called DNA polymerase gamma (pol γ), which is needed ...

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22 ...

Now, researchers at the University of Gothenburg have discovered a small molecule that restores function in a defective mitochondrial enzyme, offering a new therapeutic avenue for diseases caused by ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

POLG disease is a mitochondrial disorder caused by inherited mutations in the POLG gene—which is critical to the processes of replicating cells’ genetic material and DNA repair. The disease ...

Researchers from Pretzel Therapeutics Inc. and the University of Gothenburg have published new insights on how mutations in the POLG gene affect its functionality and are tied to PolG diseases. They ...

It is named for the POLG gene, and there are more than 200 POLG mutations that can cause the disease. The POLG Foundation described the disorder as robbing cells of energy and comparing it to a ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...