Techniques for inducing pluripotency are rapidly evolving, but researchers working with already-pluripotent cell lines must navigate the tricky waters of maintaining culture conditions for growth and ...

These studies helped make Oct4's role in development clear: “Without Oct4, there is no pluripotency,” summarized Schöler. “Things take longer, but the iPS cells that you obtain are of much higher ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances.

Sometimes, however, they fail to provide irrefutable proof of the pluripotency of the reprogrammed cells – even when the corresponding results have been published in prestigious scientific journals.

How are induced pluripotent stem (iPS) cells different from embryonic stem (ES) cells? What can we use iPS cells for? ES cells were originally derived from the inner cell mass (ICM) or epiblast of ...

Otonkoski lab is interested in nuclear reprogramming and genome editing, and how these can be applied to understand mechanisms behind pancreatic beta-cell failure leading to diabetes. We also operate ...