When the researchers inhibited Plk1 in living cells, the cells remained in the prophase of mitosis for up to 10 hours—this normally only takes about 15 minutes. In this phase, the cell prepares ...

(B) Illustrates a specific example. During mitosis, Plk1 phosphorylates Nedd1 at several sites, which is further recognized by γ-tubulin. The complex of Nedd1 and γ-tubulin together localizes to ...

Steegmaier and colleagues, writing in Current Biology, have identified an inhibitor of polo-like kinase 1 (PLK1 ... growth through the inhibition of mitosis. Next, the authors examined ...

When the researchers inhibited Plk1 in living cells, the cells remained in the prophase of mitosis for up to ten hours – this normally only takes about fifteen minutes. In this phase, the cell ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Cardiff Oncology, Inc. is an oncology therapeutics company, which engages in the development of drugs that target mitosis for the ... Polo-like Kinase 1 (PLK1) inhibitor, in combination with ...