Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

In this study, researchers found that the molecule PLK1 promotes the degradation of PDCD4, causing the activation of a pathway that clears some drugs and promotes proliferation. "These results ...

Erroneous or uncontrolled cell division can have serious consequences, leading to diseases such as cancer. Plk1 plays a key role in this regulatory process. It activates other proteins involved in ...