View Full Profile. Learn about our Editorial Policies. Since then, many scientists, including Lu, who now leads his own research group at Western University, have shown that PIN1 is overexpressed in ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...