New research reveals that sugar metabolism in brain cells may be a crucial defense against Alzheimer’s and related dementias.

Thymidine phosphorylase is an angiogenic factor primarily expressed by cancer cells, stromal cells and tumour-associated macrophages in many human malignancies. These different types of thymidine ...

Findings suggest boosting glycogen breakdown may reduce neurodegeneration linked to Alzheimer’s, dementia - Anadolu Ajansı ...

Demonstrated strong safety and favorable pharmacokinetics in Phase 1 study A First-in-class oral small molecule modulating immune cell metabolism via glycogen phosphorylase inhibition Once-daily ...

Experiments with UPP1-expressing K562 cells showed that elevated uridine phosphorylase activity in a sugar-free medium supplemented with RNA facilitated cell growth in the complete absence of glucose.

This study examined the relationship of thymidine phosphorylase expression in patients with advanced colorectal cancer to tumor response during 5-FU-based chemotherapy.

Capecitabine is transformed to FU in several steps, the last of which is conversion of 5′-deoxy-5-fluorouridine to FU by thymidine phosphorylase (TP). Capecitabine was designed to take advantage of ...

McArdle’s disease, also known as Glycogen Storage Disease Type V, or GSD5, is a congenital disorder of muscle metabolism. This article discusses the disease in more detail.

A phase II trial to evaluate pemetrexed clinical responses in relation to tumor methylthioadenosine phosphorylase (MTAP) gene status in patients with previously treated metastatic urothelial carcinoma ...