Cholesterol enhances the fluidity and stability of the nanoparticle, facilitating its fusion with cellular membranes. Polyethylene glycol (PEG)-lipids are included to prolong the circulation time by ...

Serina Therapeutics, Inc. (“Serina”) (NYSE American: SER), a clinical-stage biotechnology company developing its proprietary POZ Platform ™ drug optimization technology, announced that Randall ...

including Chol and fusogenic lipids, and a PEG lipid (Table 2). In SNALPs, the backbone-modified siRNA is encapsulated within a closed shell of a cationic-zwitterionic lipid bilayer, furnished ...

1). Their lipid compositions were almost identical, except for the addition of a very small percentage of PEG-lipid molecules, which appears to prevent the internalization of Construct II vesicles.

In contrast, polyethylene glycol (PEG)-lipid standards, commonly used in current LNP formulations, elicited a strong and boosted antibody response. Anti-PEG antibodies have been implicated as a ...

a key component of lipid nanoparticles (LNPs), did not trigger an IgM or IgG antibody response following repeat dosing in rats. In contrast, polyethylene glycol (PEG)-lipid standards, commonly used in ...