One such target may be the ubiquitously expressed nonreceptor protein-tyrosine phosphatase PTP1B encoded by Ptpn1. Consistent with early studies implicating PTP1B as a negative regulator of ...

The study shows that by inhibiting the protein tyrosine phosphatase PTP1B in T cells, the body's immune response to cancer can be mobilized, helping to repress tumor growth. A collaborative study ...

MD-18 represents a breakthrough in targeting protein-tyrosine phosphatase 1B (PTP1B), a therapeutic target that has been shown to play a major role in glucose homeostasis and energy metabolism.

Northridge Health Group (Hong Kong) Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a tyrosine-protein ...