Researchers at the Alzheimer's Disease Research Center at the University of Washington in Seattle are modifying their grant ...

However, less than 1% of cases result from inherited mutations in three specific genes: Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and Amyloid Precursor Protein (APP). These mutations drive the ...

We now know the gene, called presenilin 1 (PSEN1), that is responsible for this family’s disease. Knowing the gene mutation means we can predict which family members will get Alzheimer’s.

Scientists have detected that a previously overlooked gene behavior could potentially lead to a new way to diagnose Alzheimer's earlier. Published in the journal Epigenetics, an international ...

Several genetic variants in APP, PSEN1, and PSEN2 fit the bill, but not all. A study led by Jorge Llibre-Guerra of Washington University in St. Louis, published February 4 in Brain, explains how the ...

The laboratory of Prof. Chávez Gutiérrez at the VIB-KU Leuven Center for Brain & Disease Research recently demonstrated that mutations in PSEN1 correlate strongly with age of onset for Alzheimer ...

This effect was specific to expression of the mutant PSEN1 in that the survival and differentiation of progenitors in mice overexpressing wild-type human PSEN1 were similar to nontransgenic mice (Wen ...

For many years, Arboleda-Velasquez and an international team of scientists have been studying a large cohort of related individuals in Colombia who have ADAD caused by a mutation called PSEN1-E280A.

As researchers at Massachusetts General Hospital (MGH) and other centers first described in 2019, the woman, from Medellin, Colombia, was a member of an extended family with a mutation in a gene ...