PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

TgF344-AD rats express human APP with the Swedish mutation and human PSEN1 with the Δ exon 9 mutation. Both transgenes are driven by the mouse prion promoter (Cohen et al., 2013). Compared with levels ...

being expressed predominantly in microglia and / or astrocytes. In our laboratory, we have recently demonstrated that astrocytes carrying early-onset AD-associated mutation in PSEN1 gene display a ...