p53 normally functions to gauge DNA damage ... low-risk HPV strains share a specific amino acid difference in their pRb binding site (aspartic acid 21 in HPV-16 E7 vs glycine 22 in HPV-6 E7 ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...